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But an experiment on adult mice showed that excessively high supplements of DHA without arachidonic acid supplementation can impair physical and cognitive performance [*59]. Arachidonic acid may facilitate LTP-type learning in the hippocampus of the brain [*51]. An experiment studying maze-learning in rats demonstrated that, after training, the rats showed less cholesterol and more membrane fluidity in the hippocampal and cortical regions of the brain [*60]. Adult mice fed fish oil for 12 months showed more brain hey fatty boom boom DHA, less brain arachidonic acid, more synaptic membrane fluidity hey fatty boom boom and higher maze-learning ability [*61]. Rats hey fatty boom boom fed perilla oil showed 30% more hippocampal neuron synaptic vesicle density and improved learning compared to rats fed safflower oil [*62]. Measurements of fatty acid content of brain cell (neuron) membranes show decreased DHA with aging. Since DHA is particularly concentrated in synaptic membranes, lowered DHA levels may contribute to declining brain function.
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