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international food information council foundation, membrane, fat girls com , n 9, 2003, plump hardcore , plump tits , sore, hempseed, anemia, eicosanoids, plump asian , But an experiment on adult mice showed that excessively high supplements of DHA without arachidonic acid supplementation can impair physical and cognitive performance [*59]. Arachidonic acid may facilitate LTP-type learning in the hippocampus of the brain [*51]. An experiment studying maze-learning in rats demonstrated that, after training, the rats showed less cholesterol and more membrane fluidity in the hippocampal and cortical regions of the brain [*60]. Adult mice fed fish oil for 12 months showed more brain hey fatty boom boom DHA, less brain arachidonic acid, more synaptic membrane fluidity hey fatty boom boom and higher maze-learning ability [*61]. Rats hey fatty boom boom fed perilla oil showed 30% more hippocampal neuron synaptic vesicle density and improved learning compared to rats fed safflower oil [*62]. Measurements of fatty acid content of brain cell (neuron) membranes show decreased DHA with aging. Since DHA is particularly concentrated in synaptic membranes, lowered DHA levels may contribute to declining brain function.
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Recent experiments testing relative concentrations of linoleic acid to alpha-linolenic acid in the range of from 3-to-1 to 6-to-1 verified that a 4-to-1 ratio is optimal for spatial learning and pain 2003 tolerance in rats [*56]. The influence of 2003 essential fatty acid supplement on brain membrane content declines with maturity, however. Adult cell membrane content of DHA and arachidonic acid is only slowly altered by diet or supplement. If dietary intake of essential fatty acid is low, 2003 the body will sacrifice essential fatty acid content of cell membranes outside the brain before neurons are affected. A study of elderly men, however, showed greater cognitive impairment among those with a history of high dietary linoleic acid compared with controls, whereas those with high fish consumption showed reduced cognitive decline [*57]. One experiment showed promotion of neuron growth by DHA and inhibition by arachidonic acid [*58].
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