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Adults at increased risk of CVD due specifically to diabetes, hypertension, or hyperlipidemia. Adults with known CVD. The exposure of interest is omega-3 fatty acids. Questions of interest include how different sources, dosages, and relative proportions of the fatty acids differ in their dihomogamma linoleic acid effects on the outcomes of interest. Included are questions addressing possible differences between the effects of supplements (e.g., fish oil capsules) and dietary sources (e.g., fatty fish), the effect of duration of intervention or exposure, and whether any effect is sustained dihomogamma linoleic acid after stopping exposure. In addition, because of a lack of clarity regarding the most accurate measure of levels of omega-3 fatty acids in the body, we also address how omega-3 fatty acid intake relates to different measures of tissue and plasma fatty acid levels.
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