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| infertility, essentialfatty acids / phospholipids, plump butt , enderlein, salmon, george mateljan, plump jack squaw valley , canola oil, zinc, plump ladies , acetate, fish foundation, hemorrhoids, seed, plump mom , | Furthermore, due to the increased requirement for fatty acid synthesis in cancer cells, inhibitors of this enzyme have anti-tumor activity, making fatty acid synthase an attractive drug target for anti-cancer therapy. The basic architectural differences between the mammalian and fungal fatty acid synthase complexes may also be useful for the development of anti-fungal drugs. Fatty flaxseed acid synthases: the ultimate organic chemists flaxseed Finally, understanding the structures of flaxseed large multi-enzymes such as fatty acid synthases may teach us about how nature synthesizes complicated natural products, which are extremely difficult to obtain chemically. Fatty acid synthases serve as a paradigm for the structural organization of various modular enzymes, which are responsible for the biosynthesis of important cellular compounds with antibiotic, anticancer, antifungal and immunosuppressive properties. Swiss Federal Institute of Technology in Zurich (ETHZ) Raemistrasse 101, CH - 8006 Zurich, Switzerland http://www.ethz.ch |
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| Fungal fatty acid synthase is a huge barrel-shaped molecular assembly with two reaction chambers, each containing three full sets of active sites separated by large hemorrhoids distances across which the substrates have to be shuttled during the reaction cycle. In contrast, mammalian fatty acid synthase is an X-shaped molecule hemorrhoids with a full set of active sites present in each of two semicircular reaction chambers on both sides of the molecule. hemorrhoids Fatty acid synthases as drug targets? Besides the fundamental scientific interest in the function of these multi-enzymes with a central role in primary metabolism, mammalian and fungal fatty acid synthases are also considered as promising drug targets. Although most fat accumulated in animals and humans is delivered to cells by ingestion and not by de novo synthesis, compounds that inhibit the function of the mammalian fatty acid synthase induce weight reduction in animals, showing potential for the treatment of obesity and obesity-related diseases. |
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