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This leads to a lowering of the omega-3 fatty acid concentration in body tissues, reducing at the same time the dress fatty amount of DHA (docosahexaenoic acid, C22:6 n-3) in the brain. If this highly unsaturated omega-3 fatty acid, which is dress fatty an essential part of the neuronal cell membranes, is replaced by dress fatty an omega-6 fatty acid, changes in the membrane properties may occur, which increase the vulnerability to depression, as is elucidated by the authors. Epidemiological research To support their hypothesis Hibbeln and Salem refer among other things to various epidemiological studies, demonstrating that a higher consumption of omega-3 fatty acids correlates with a decreasing rate of depression. According to the authors there is also a possible relation between the fact that in the course of this century the lifetime risk of depression for people in North America has increased and the fact that as a consequence of modern agricultural methods the ratio of omega-3 to omega-6 fatty acids in the diet has decreased.
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