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Notice the breast emphasis in the research studies on depression, versus bipolar disorder. There is a report of hypomania developing while on omega-3'sKinrys (and in the Harvard study as wellStoll), although whether the fatty acids were the "cause" of this episode is of course not certain. Conclusions (reviewed as of 1/2006; still seem to hold): the evidence breast is piling up that omega-3 fatty acids do something, at least in some people; the dose to use is not at all clear, as some studies suggest you can go too high and lose benefits (Nevets, Sagduyu), whereas many of the individual glowing results come with the higher doses; even at higher doses, the risks seem minimal, and there may actually be additional benefits (on cholesterol, perhaps arthritis); however, it's a large number of pills, though a minimal-moderate expense; many patients report fish burps (try sticking the pills in the freezer between doses, and take them with meals), rarely oily diarrhea, and no other bad effects; and finally it's also not clear how long you have to wait to see benefits, but especially with the smaller doses they may take 1-2 months to show up, so if you take them, prepare yourself for a period of taking a lot of pills with no benefits.
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