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In a subsequent trial, adhd Kremer [90] measured neutrophil LTB4 production, which was decreased in the patients receiving fish oil. The prolonged suppression of LTB4 beyond the period of supplementation with fish oils most likely accounted for the continued clinical benefits observed after the period adhd of discontinuation of fish oil. Prolonged effects on the immune system were subsequently reported in normal volunteers ingesting fish oil. Therefore, a crossover format is not appropriate to study the clinical or immune effects of fish oil in patients with inflammatory disease [44]. In a study [91] which examined potential mechanisms of adhd EPA + DHA supplementation in patients with rheumatoid arthritis, 12 patients with active disease consumed 3.6 g EPA and 2.4 g DHA daily for a period of six weeks. After six weeks of fish oil ingestion, LTB4 was decreased by 33%, and there was a 37% decrease in the quantity of platelet activation factor (PAF).
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