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Excessive intake of 6 fatty acids characteristic of Western diets produces an imbalance of 6 to 3 PUFAs which leads to an overproduction of the proinflammatory prostaglandins of the 6 series and cytokines. Supplements of LA rich vegetable oils increase IL-1 fatty girl lyrics and TNF. Humans given 3-rich flax seed fatty girl lyrics oil or fish oil supplements have sharply reduced stimulated production of IL-1, IL-2 and TNF, as well as suppressed fatty girl lyrics mononuclear cell proliferation and expression of IL-2 receptors. Thus, in humans, LA increases proinflammatory cytokine secretion, whereas fish oil reduces proinflammatory cytokine secretion. Experimental studies have provided evidence that incorporation of omega-3 fatty acids modifies inflammatory and immune reactions, making omega-3 fatty acids potential therapeutic agents for inflammatory and autoimmune diseases. Their effects are brought about by modulation of the type and amount of eicosanoids and cytokines and by altering gene expression.
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