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This signal contains pre-programmed instructions, which may initiate cancer cell growth through an unknown mechanism. Therefore, when whole grains a high-fat diet is consumed, more PPARs are activated. When more receptors are activated, a greater number of signals that increase cancer growth are initiated. Scientists have found that one of these PPARs, the PPAR whole grains gamma, is a link between a high-fat diet and the development of colon cancer. Researchers are now studying this receptor to find out if it plays a similar role in prostate cancer. Epidemiologic studies have shown that high-fat intake increases a man's whole grains risk for advanced prostate cancer. Giovannucci and colleagues of Harvard Medical School found that men who ate high-fat diets (including large amounts of red meat) had a significantly higher rate of advanced prostate cancer.
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