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Low dose or intermittent NSAIDs will be permitted. Patients receiving drugs which affect lipid metabolism, such as HMG CoA inhibitors, high-dose niacin, gemfibrozil, and others. Pregnant patients - due to adenylate cyclase the unknown effects of high dose omega-3 fatty acids on the fetus. Patients who, in the investigator's adenylate cyclase judgment pose a current serious suicidal or homicidal risk, or patients who will not likely be able to comply with the study protocol. Bipolar patients receiving clozapine. These patients will be excluded due to the likelihood of extreme treatment resistance adenylate cyclase in clozapine-treated bipolar disorder. It may be unwise to discontinue the patient's clozapine, since recurrence may occur. Also, based on uncontrolled data, clozapine may be a uniquely effective mood stabilizer, which would add a potential confound to the study. Patients who meet DSM-IV criteria for substance abuse within 1 month of this trial or substance dependence within 3 months.
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