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| disturbances, endometriosis, plump wife , fatty acids definition , 6, hplc, atkins, miss plump , complete, female, macrobiotic, plump pussies , phytoestrogen, proteomics, prevention, excercise, lipids, glycerol and fatty acids , mental illness, | Furthermore, due to the increased requirement for fatty acid synthesis in cancer cells, inhibitors of this enzyme have anti-tumor activity, making fatty acid synthase an attractive drug target for anti-cancer therapy. depression The basic architectural differences between the mammalian and depression fungal fatty acid synthase complexes may also be useful for the development of anti-fungal drugs. Fatty acid synthases: the ultimate organic chemists Finally, understanding the structures of large multi-enzymes such as fatty acid synthases may teach us about how nature synthesizes complicated natural products, which are depression extremely difficult to obtain chemically. Fatty acid synthases serve as a paradigm for the structural organization of various modular enzymes, which are responsible for the biosynthesis of important cellular compounds with antibiotic, anticancer, antifungal and immunosuppressive properties. |
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| Fungal fatty acid synthase is a huge barrel-shaped molecular assembly with two reaction chambers, each containing three full sets excercise of active sites separated by large distances across which the substrates have to be shuttled during the reaction cycle. In contrast, mammalian fatty excercise acid synthase is an X-shaped molecule with a full set of active sites present in each of two semicircular reaction chambers on both sides of the molecule. Fatty excercise acid synthases as drug targets? Besides the fundamental scientific interest in the function of these multi-enzymes with a central role in primary metabolism, mammalian and fungal fatty acid synthases are also considered as promising drug targets. Although most fat accumulated in animals and humans is delivered to cells by ingestion and not by de novo synthesis, compounds that inhibit the function of the mammalian fatty acid synthase induce weight reduction in animals, showing potential for the treatment of obesity and obesity-related diseases. |
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