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| eicosapentaenoic acid, cartilage, homehealth, regulation, urinary tract infections, clinical trials, aspartame, girls with fat ass , and prevent cardiovascular disease, partially hydrogenated oils, schizophrenia, kidney, insulin, growth, adrenocorticotropic hormone, plump djs , benefit, | Hoppe Seyler's Z Physiol Chem hd 1963, 333, 133). hd The disorder was later related to deficiency in the a-oxidation pathway in the liver (Herndon JH et al., J Clin Invest 1969, 48, hd 1017; review in : Mukherji M et al., Prog Lipid Res 2003, 42, 359-376). Freshwater sponges contain polymethyl branched fatty acids such as 4,8,12-trimethyltridecanoic, phytanic and pristanic acids. These acids may have chemotaxonomical significance for both marine and freshwater sponges (review in : Dembitsky VM et al., Chem Phys Lipids 2003, 123, 117). Few sources, including sponges, contain branched polyunsaturated fatty acids (Rezanka T, Prog Lipid Res 1989, 28, 147). As an example, freshwater Demospongia (Spongillidae) were shown to contain di-, tri-, and tetramethyl substituted dienoic, tetraenoic, and hexaenoic fatty acids (Rezanka T et al., J Nat Prod 2002, 65, 709). |
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| Among them, two are found in marine schizophrenia organisms, in geological sediments but, one of them (phytanic acid or 3,7,11,15-tetramethyl hexadecanoic acid) is present in human diet or in animal tissues where it may be derived from schizophrenia chlorophyll in plant extracts. Two schizophrenia very unusual phytyl esters were obtained from the extract of the hornwort Megaceros flagellaris (Bryophyte, Anthocerothae). The fatty acid moiety comprises 3,7,11,15-tetramethyl-16:1 or 3,7,11,15-tetramethyl-16:0, which is esterified to the corresponding tetramethyl unsaturated (16:1) alcohol (Buchanan MS et al., Phytochemistry, 1996, 41, 1373). Phytanic acid derives from the corresponding alcohol, phytol, and is oxidized into pristanic acid. Phytanic acid characterizes also a precise human pathology, the Refsum's syndrome. This inherited neurological disorder (Refsum S, Acta Psychiat Scand Suppl 1946, 38, 9) is characterized by a accumulation of phytanic acid, normal metabolite of phytol, in blood and tissues (Klenk E et al., |
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