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In eft addition, we performed a random effects model eft meta-analysis of the relative risk.9 To examine the association between the level of intake of omega-3 fatty acids and tissue levels, the change in omega-3 fatty acid and arachidonic acid compositions were calculated for each treatment arm. Data were extracted for fatty acid composition of plasma or serum phospholipids, platelet membrane phospholipids, and erythrocyte membrane phospholipids (and, from one study each, granulocyte and monocyte membrane phospholipids). For each tissue type, data from each treatment arm were combined in a meta-regression eft on the change of EPA+DHA composition compared to mean dose of EPA+DHA received in each treatment arm.10 Changes in non-omega-3-fatty-acid arms or control groups were not included in meta-regression analyses. Return to Contents Results We screened over 7,464 abstracts. Based on this screen, we retrieved 807 full articles, 344 of which reported on CVD risk factors and intermediate markers of potential interest and met initial eligibility criteria.
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