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diabetics), studies generally did not base eligibility unsaturated fat criteria on factors of particular interest unsaturated fat here. Most conclusions that unsaturated fat we were able to draw were based on across-study comparisons (particularly for different populations), which cannot account for confounders. Furthermore, the potential effect of ALA is unknown. Our analyses were further limited by factors inherent to evaluation of CVD risk factors and intermediate markers. While some of these markers have indeed been demonstrated to be important markers or risk factors for CVD, it is unclear whether all of the factors are. The measurement techniques for a number of the outcomes evaluated also have not been standardized, which complicates interpretation of individual study findings and limits the ability to compare studies. Thus, the meaning in terms of CVD risk of omega-3 fatty acids on various putative risk factors and intermediate outcomes is uncertain.
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