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Epidemiological, Clinical Trial, and Nonhuman Primate Evidence for the Relationship Between Type of Fat and Coronary Disease As study designs have become increasingly rigorous, a number of megatrends have emerged from the data.1 2 There is increased emphasis on identifying the type of fat that best correlates with disease end points. The classic studies of Keys fattyacid metabolism et fattyacid metabolism al3 and Hegsted et al4 have shown that saturated fatty acids (ie, those with a carbon chain length of C12:0 to C16:0) raise total and low-density lipoprotein (LDL) cholesterol fattyacid metabolism levels, whereas C18:0 and monounsaturated fat (cis C18:1) are neutral when substituted for carbohydrate, and n-6 polyunsaturated fatty acids (PUFAs) lower cholesterol.3 4 More recent studies have shown that long-chain n-3 fatty acids are hypotriglyceridemic and trans fatty acids are hypercholesterolemic.
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