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Question-specific synopses follow. Question 1 (Impact on Respiratory Outcomes) Ten RCTs and nine studies employing other designs (i.e., non-randomized controlled trials [non-RCTs]; noncomparative case series) addressed Question 1. Of the RCTs, mens hea two exclusively randomized children,24,25 one included both mens hea older adolescents and adults,26 one did not report any age data,27 and six focused on adults.17,28-32 Two non-RCTs focused on children22,33 and seven other studies enrolled adults.19,21,34-38 Of the latter, one was a non-RCT21 and six mens hea involved noncomparative case series.19,34-38 Given the largely inconsistent picture of efficacy within and across respiratory outcomes, it is impossible to conclude one way or the other whether omega-3 fatty acids are an efficacious adjuvant or monotherapy in improving respiratory outcomes in adults or children.
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