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This view is perhaps best illustrated by what was observed with respect to the primary outcome, FEV1. Adult RCTs revealed a somewhat contradictory picture of efficacy with respect to FEV1. One very small adult study (n = 14) that employed uncontrolled dosing of perilla seed oil and corn oil (control) over a short intervention period (n = 4 wk) reported a significant effect. However, two RCTs each observed no benefit relating to an omega-3 fatty acid intervention. One compared high focal fatty sparing and low doses of EPA ethyl ester31 over 16 focal fatty sparing weeks in focal fatty sparing a small study (n = 12), whereas the second investigated the benefit of low-dose EPA/DHA (versus olive oil) over 10 weeks in the systematic review's highest quality RCT.32 |
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