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Additionally, growth inhibition in vitro does not necessarily correlate with the degree of lipid peroxidation (13) and antioxidants preventing lipid peroxidation in vitro do not completely reverse the effects Of certain PUFAs on cell growth. (11,12,14) Researchers found that administering LA without antioxidants also reverses the suppressive effects of fish oil on the growth of colon adenocarcinoma in huntington's mice. (20) Further research has found that preventing lipid peroxidation in experimental diets by the addition of antioxidants does not huntington's interfere with the growth inhibitory effects of fish oil on primary tumor growth or huntington's the development of metastases in nude mice with transplanted human breast and prostate cancer cells. (21-23) These results suggest PUFAs are cytostatic and cytotoxic in vitro and in vivo when conditions allow lipid peroxidation to occur, but that certain PUFAs in the absence of oxidative stress also have inhibitory effects on tumor cell growth.
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