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record types: factsheet, level, food science, omega3 fatty acid , suzanne munson, nutrition facts, anti inflammatory herb, ayurveda, infertility, essentialfatty acids / phospholipids, plump butt , enderlein, salmon, george mateljan, plump jack squaw valley , canola oil, | Choline plasmalogen is abundant in cardiac tissue. One particular choline alkyl ether plasmalogen (1-O-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine) has been identified as an extremely powerful biological mediator, capable of inducing cellular responses at concentrations as low as 10-11 M. This molecule is called platelet activating factor, PAF. solubility PAF functions as a solubility mediator of hypersensitivity, acute inflammatory reactions and anaphylactic shock. PAF is synthesized in response to the formation of antigen-IgE complexes on the surfaces solubility of basophils, neutrophils, eosinophils, macrophages and monocytes. The synthesis and release of PAF from cells leads to platelet aggregation and the release of serotonin from platelets. PAF also produces responses in liver, heart, smooth muscle, and uterine and lung tissues. Platelet activating factor back to the top Metabolism of the Sphingolipids The sphingolipids, like the phospholipids, are composed of a polar head group and two nonpolar tails. |
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The products of these phospholipases are called lysophospholipids and can be substrates for acyl transferases utilizing different acyl-CoA groups. Lysophospholipids can also accept acyl groups from other phospholipids in an exchange reaction catalyzed by omega3 fatty acid lysolecithin:lecithin acyltransferase (LLAT). Phospholipase A2 is also an important enzyme, omega3 fatty acid whose activity is responsible for the release of arachidonic acid from the C-2 position of membrane phospholipids. The released arachidonate is then a substrate for the synthesis omega3 fatty acid of the prostaglandins and leukotrienes. back to the top Plasmalogens Plasmalogens are glycerol ether phospholipids. They are of two types, alkyl ether (-O-CH2-) and alkenyl ether (-O-CH=CH-). Dihydroxyacetone phosphate serves as the glycerol precursor for the synthesis of glycerol ether phospholipids. Three major classes of plasmalogens have been identified: choline, ethanolamine and serine plasmalogens. Ethanolamine plasmalogen is prevalent in myelin. |
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