|
record types: factsheet, level, food science, omega3 fatty acid , suzanne munson, nutrition facts, anti inflammatory herb, ayurveda, infertility, essentialfatty acids / phospholipids, plump butt , enderlein, salmon, george mateljan, plump jack squaw valley , canola oil,
|
There are 3 forms of the COX activity. COX-1 (PGS-1) is expressed constitutively in gastric mucosa, kidney, platelets, and vascular endothelial cells. COX-2 (PGS-2) is audience: teachers/education professionals inducible and is expressed in macrophages and monocytes in response to inflammation. The primary trigger for COX-2 induction in monocytes and macrophages is audience: teachers/education professionals platelet-activating factor, PAF and interleukin-1, IL-1. Both audience: teachers/education professionals COX-1 and COX-2 catalyze the 2-step conversion of arachidonic acid to PGG2 and then to PGH2. Most recently a splice variant of COX-1 mRNA has been found in many tissues such as heart, kidney and several neuronal tissues. This variant mRNA retains intron 1 from the COX-1 gene and the encoded protein has been termed COX-3. In vitro evidence indicates that the canine COX-3 enzyme is inhibited by acetominophen.
|
