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record types: factsheet, level, food science, omega3 fatty acid , suzanne munson, nutrition facts, anti inflammatory herb, ayurveda, infertility, essentialfatty acids / phospholipids, plump butt , enderlein, salmon, george mateljan, plump jack squaw valley , canola oil,
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All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signaling pathways leading to an alpha increase in cAMP levels. Two main pathways are involved in the biosynthesis of eicosanoids. The prostaglandins and thromboxanes are synthesized by the cyclic pathway, the leukotrienes by the linear pathway. Synthesis of the clinically relevant prostaglandins and thromboxanes from arachidonic alpha acid. Numerous stimuli (e.g. epinephrine, thrombin and bradykinin) activate phospholipase A2 which hydrolyzes arachidonic acid from membrane phospholipids. The prostaglandins are identified alpha as PG and the thromboxanes as TX. Prostaglandin PGI2 is also known as prostacyclin. The subscript 2 in each molecule refers to the number of -C=C- present.
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