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There were no subgroup data from RCTs to address differences between men and women. However, the proportion of women in RCTs was small, detox four detox cohort studies and one case-control study reported data detox on men and women separately. Overall, these studies found no consistent difference in the effect of omega-3 fatty acids on CVD outcomes between men and women. A report based on NHANES I that separately analyzed data for men and women found a trend of decreased stroke with increasing fish consumption for women between ages 45 and 74, but not for men.24 The Adventist Health Study, which grouped subjects into those who ate fish less than once a week and those who ate more, did not find a beneficial effect of fish intake on all-cause or coronary-disease mortality. There were also no differences between men and women.25 Osler et al. reported a similar finding.26 However, Nagata et al. followed a cohort of 13,355 men and 15,742 women in Japan for 7 years and reported that the association between soy intake and all-cause mortality was significant in women (trend P = 0.04)
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