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CVD question 1c. Key question fatty ratty 1c. asks about the effects of potential confounders on associations found in prospective cohort studies. Because only summary data about potential confounders was available (and this data was insufficiently detailed), we were unable to analyze the effect of confounders across studies. To fully answer question 1c. fatty ratty would require a meta-analysis of the original data from the cohort studies. Only one study addressed the potential confounding effect of a specific variable (i.e., fatty ratty aspirin treatment).32 Iso et al. analyzed subgroups of women in the Nurses' Health Study who took aspirin regularly versus those who did not.30 Stroke events were reduced in both groups at most levels of fish intake, and a statistically significant trend with increasing fish consumption was found in women who did not take aspirin regularly.
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