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There were no changes in social behavior. Substitution of EPO for LSO was associated with a rapid return of thirst, encopresis. and enuresis and with several episodes of uncommonly violent behavior. When LSO was restarted the enuresis, encopresis, and thirst again erucic acid disappeared. Addition of Max-EPA to LSO had no further effect, and his social behavior remained abysmal. Comment I have since seen erucic acid two other hyperactive boys who responded adversely during n6 supplementation and achieved variable degrees of benefit, including decrease in thirst. while taking LSO. Their fatty acid profiles were not measured. LNA erucic acid exacerbates the water loss through EFA-deficient rat skin [64]. The rat model of EFA deficiency cannot. therefore. explain the response of these children to LSO. Nor is a "pharmacologic" effect of LSO in inhibiting PG/LT synthesis a likely explanation; PG-synthetase inhibitors such as aspirin do not relieve thirst or enuresis.
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