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| unsaturation, essential fatty acids in human, acetic acid, food allergies, saturated and unsaturated fatty acids , omega 3 benefits, freudian slip, energy, polyunsaturated fatty acids, hydrogenation, vegan, plump jack squaw valley inn , edward n. siguel, consumer health, health & fitness, plump dj , chemokines, cat, 2006, aches and pains, | All dietary fatty acids are incorporated into cell membranes, and the type of fatty acids dictates how adenosine triphosphate a adenosine triphosphate cell responds and grows. Researchers found that omega-3 fatty acids affect cell growth by activating an enzyme called sphingomyelinase, which then generates the release of ceramide, a compound that induces the expression of the human tumor suppressor gene p21, which ultimately causes cancer cell death. In the animal experiments, mice were fed diets rich in either omega-3 (fish oil) or omega-6 (corn oil) fatty acids after which breast cancer cells were implanted. Three weeks later, tumor volume and weight was significantly adenosine triphosphate lower in mice on the omega-3 rich diet. In the lab culture experiments, when cells were treated with DHA or EPA, sphingomyelinase activity increased by 30-40%, and breast cancer cell growth dropped 20-25%. |
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| On the other hand, diets rich in omega 3 fats produce cell membranes with a high degree of fluidity. In addition, recent in vitro (test tube) evidence suggests when omega 3 fatty health & fitness acids are incorporated into cell membranes they may help to protect against cancer, notably of the breast. They are suggested to promote breast cancer cell apoptosis via several mechanisms including: inhibiting a health & fitness pro-inflammatory enzyme called cyclooxygenase 2 (COX 2), which promotes breast cancer; activating a type of health & fitness receptor in cell membranes called peroxisome proliferator-activated receptor (PPAR)-ã, which can shut down proliferative activity in a variety of cells including breast cells; and, increasing the expression of BRCA1 and BRCA2, tumor suppressor genes that, when functioning normally, help repair damage to DNA, thus helping to prevent cancer development. Animal and test tube studies published in the November 2005 issue of the International Journal of Cancer suggest yet another way in which the omega-3 fatty acids found in cold water fish—docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)—help protect against breast cancer development. |
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