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| acids, benefits of omega 3 fatty acids, 1930, omega 6, fattyacid, plump thighs , chemotherapy / health aspects, 0964253402, menu, cell, fat girls pictures , headache, big plump plumpers galleries , | The arachidonic acid animations products LeukoTriene B4 (LTB4) and ProstaGlandin E2 (PGE2) are powerful promoters of inflammation. LTB4 is only formed in granulocytes subject to stimuli favoring action by 5-lipoxygenase activating protein [ARCHIVES OF BIOCHEMISTRY animations AND PHYSICS 356(1):71-76 (1998)]. Both PGE2 & LTB4 increases tissue swelling (edema) by making the vascular endothelium more leaky. LTB4 stimulates superoxide production by neutrophils, activates Natural Killer cells and powerfully attracts inflammatory leukocytes. PGE2 increases sensitivity to pain, raises temperature and increases the formation of the allergic antibody Immunoglobulin E (IgE) [*17]. Aspirin irreversibly blocks the enzyme animations cyclo-oxygenase, which prevents arachidonic acid from being converted to prostaglandin -- thereby limiting inflammation and pain. Gamma-tocopherol (the major form of Vitamin E in food, in contrast to alpha-tocopherol, which is the major form of Vitamin E in supplement pills) also blocks cyclo-oxygenase and reduces proinflammatory PGE2 & LTB4 formation [FASEB JOURNAL 17:816-822 (2003)]. |
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| Both systems make use of phagocytes (cells that "eat" foreign substances) and antibodies (Y-shaped chains of proteins known as immunoglobulins). Acquired immunity is seen when the immune system has identified a foreign protein as being an antigen. For innate immunity, however, there cell is a generalized reaction against tissue trauma and infectious agents that could as easily cell be described as inflammation as immunity. The swelling of inflammation is associated with immunoglobulin-E (IgE) and with an increased blood vessel permeability which allows Natural Killer cells, cell macrophages and neutrophils to leave the blood stream, migrate to the injured area and engulf the invaders. Although innate immune defense is not very specific, it is rapid. By contrast, the immune cells (lymphocytes) and immunoglobulins (IgM and IgG) of acquired immunity are slower to develop, but can be very powerful and very specific against antigens. The eicosanoids produced from arachidonic acid cause a stronger inflammatory response than the eicosanoids from EPA or DGLA. |
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