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PGE2 is known to suppress lymphocyte proliferation, to suppress synthesis of chemical factors (lymphokines) fat girls influencing the immune system and to contribute to the auto-immune diseases that increase with aging [*30]. (return to contents) VII. FATS AGAINST CANCER High fat diets are well-known to be associated with certain kinds of cancers, fat girls including breast fat girls cancer, in particular [*31]. Although butterfat stimulates breast cancer when compared with a fat-free diet, safflower oil margarine (linoleic acid, an omega-6) has been shown to induce breast cancer much more strongly [*6]. Linoleic acid is the fat that most frequently is associated with cancer, whereas omega-3 fatty acids like DHA and perilla-oil suppress cancer [*32,*33]. It has been theorized that linoleic acid causes cancer by chronic overproduction of the inflammatory arachidonic acid eicosanoids, which stimulate the proliferation of mutated cells [*6]. PGE2 resulting from COX-2 enzyme is found in high levels in colorectal carcinomas where the prostaglandin promotes growth through transactivation of epithelial growth factor receptor signalling.
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