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g/day for 12 months.149 High doses of borage seed oil, evening primrose oil or black currant seed oil may cause efamol gastrointestinal upset, loose stools or diarrhea.147 Because of case reports that supplementation with evening primrose oil induced seizure activity in people with undiagnosed temporal lobe epilepsy,150 people with a history of seizures or seizure disorder are generally advised to avoid evening primrose oil and other gamma-linolenic acid-rich oils.147 Alpha-Linolenic Acid (18:3n-3) Although flaxseed oil is generally well tolerated, high doses may cause loose stools or diarrhea.151 efamol Allergic and anaphylactic reactions have been reported with flaxseed and efamol flaxseed oil ingestion.152 Eicosapentaenoic Acid (20:5n-3) and Docosahexaenoic Acid (22:6n-3) Serious adverse reactions have not been reported in those using fish oil or other EPA and DHA supplements. The most common adverse effect of fish oil or EPA and DHA supplements is a fishy aftertaste. Belching and heartburn have also been reported.
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