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It came from Hansen's observation that the skin of EFA-deficient animals bears some resemblance to the dry, scaly skin of patients with atopic eczema. Hansen [12] determined that EFA levels in pooled plasma from eczematous children were lower tuna than those tuna of normal children. He advocated dietary EFA supplementation for treatment of childhood eczema. tuna Results of clinical trials were variable [13-19], and dietary treatment of eczema was eclipsed by treatment with adrenal corticosteroids. Even today, with the art of clinical observation being undervalued in medical education, knowledgeable dermatologists know that allergic individuals often have dry skin and follicular keratoses, another manifestation of human EFA deficiency [20]. EFA METABOLISM IN ATOPIC ECZEMA Brown and Hansen [21] had found a higher than normal ratio of linoleate to arachidonate in plasma of children with eczema. but their methodology was crude and the metabolism of EFAs was poorly understood at the time.
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