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The end product of this sequence is docosapentaenoic acid (22:5 n6). Critical intermediates are dihomogamma linolenic acid (DGLA; 20:3 n6) and arachidonic acid (AA; fiber 20:4 n6), precursors of PGs and Us. The first step in this sequence is catalyzed by the magnesium-containing desaturase enzyme delta-6 dehydrogenase (D6DH). An elevation of fiber LA and a decrease in concentration of all its metabolites suggest an impairment in the activity of this enzyme. The n3 polyunsaturates appear to be affected in parallel. Their normal metabolism is reviewed in Figure lb. Levels of n3s in plasma are small and variable. so that significant changes can be hard to discern. Nonetheless, compared to controls [24] eczema patients show an elevation of alpha-linoleic acid (LNA, 18:3 n3) and a decrease in its long-chain metabolites. One of these metabolites, eicosapentaenoic acid (EPA; 20:5 n3), is a precursor of the trienoic PGs.
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