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Primrose oil was chosen because it contains 9% gamma linolenic acid (GLA. 18:3 n6), the product monounsaturated of delta-6 desaturation monounsaturated of LA. In a double-blind study using three levels of primrose oil (2.0. 4.0, and 6.0 gm daily) they found a significant, dose-dependent reduction in inflammation determined by pruritus, erythema, and scaling. EFA levels showed significant improvement as well [24]. This suggested that the intake of GLA was exerting not only a corrective effect on the usual skin signs of EFA deficiency. but an antiinflammatory and monounsaturated immunomodulatory effect. The investigators postulated that D6DH impairment in this group of atopic patients, with its resulting decrease in the levels of PG precursors, was impairing the synthesis of immunoregulatory prostaglandins [23]. STUDIES OF A HETEROGENEOUS GROUP OF ALLERGIC PATIENTS Table 1.
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