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Plasma phospholipids have lower levels of DGLA and EPA. precursors of the monoenoic and trienoic PGs. These fat plump findings are consistent with impaired desaturation of dietary fat plump EFAs, as described in patients with eczema. The variability of AA levels in the mixed atopic population suggests the influence of other regulatory mechanisms, some of which might involve n3 EFAs. PROSTAGLANDINS AND ALLERGY A central event in the expression of allergic illness is the binding of immunoglobulin E (IgE) to mast cells with resultant releases of histamine (HA) and fat plump other inflammatory mediators. In addition to acting as an effector of allergic inflammation by stimulating H I receptors, HA has immunosuppressive effects that are H2-mediated [39].
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