Although in slightly different text/html;charset=iso 8859-1 high blood pressure

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gabe mirkin, nutrition/agriculturenews, heart disease, artery damaging lipoprotein, information, crohns disease, organic, unsaturated fatty acids / health aspects, fatty acid, dinner recipe, homeopathy, fish oils, mirkin, asthma/respiratorynews, cell based assay, health supplements, drying oil, health & fitness / nutrition, chronic, omega minus three fatty acids , fat, high blood pressure, trans, Kimura et al. text/html;charset=iso 8859-1 (1995) found that DHA supplementation could to a large extent prevent an increase in blood pressure in rats genetically programmed to develop hypertension and stroke (spontaneously hypertensive rats). While the average blood pressure in the control group of young rats on “normal” diet increased form 120.2 to 202.9 mmHg during the test period, blood pressure in the DHA supplemented group only increased to 149.8 mmHg. Serum creatinine levels and blood urea nitrogen text/html;charset=iso 8859-1 were significantly text/html;charset=iso 8859-1 lower in the DHA group, which indicates beneficial changes in renal function. These experimental blood pressure lowering effects on rats have been confirmed in clinical trials on humans. Mori et al. (1999) conducted an interesting, double-blind, placebo-controlled trial with 59 overweight, hyperlipidemic men to compare the effects of purified EPA, DHA and olive oil supplementation (4g/d in capsules).
Although high blood pressure in slightly different ways, both GLA and DHA decreased the production of aldosterone. In the GLA study the aldosterone/renin ratio was significantly lower in the borage oil group than in the control group given sesame oil. In the DHA study aldosterone was significantly lowered (33%) compared to the control group fed a high blood pressure diet containing corn/soybean oil. A high blood pressure remarkable reduction of the systolic blood pressure was also seen in both studies. In the borage oil group the decrease was 12 mmHg after three weeks, and in the DHA study the blood pressure was 34 mmHg lower on an average after six weeks. The observations in these studies suggested that borage oil (GLA) inhibits the adrenal responsiveness to angiotensin II through diminished angiotensin receptor activity in aldosterone producing cells. Decreased aldosterone levels stimulate renin secretion and the net effect is a desirable reduction in the aldosterone/renin ratio. DHA on the other hand, appears to affect the aldosterone production without involving angiotensin receptors.
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