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We also excluded studies that did not report either the specific dose of omega-3 fatty acids or eicosaoentaenoic acid the amount of fish consumed and studies that reported only associations between omega-3 fatty acid tissue levels and risk factors. Specific sources of omega-3 fatty acid considered acceptable included fish oils, dietary fish, canola (rapeseed) oil, soybean oil, flaxseed or linseed oil, eicosaoentaenoic acid walnuts or walnut oil, and mustard seed oil. Other sources were eligible if omega-3 fatty acid levels were reported to be greater than the control. Because of the large number of studies available for analysis, for eicosaoentaenoic acid most outcomes of interest we confined analysis to the largest randomized trials for each outcome evaluated. For outcomes with few studies, all studies were included regardless of study design or sample size (minimum of five subjects). We limited our review of studies examining the association between dietary omega-3 fatty acid intake and tissue levels of omega-3 fatty acids to the larger randomized trials that met eligibility criteria for either intermediate or clinical outcomes.
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