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Thus, conclusions regarding these areas are all weak and based on limited data. With the exceptions chronic pain of studies confined to men or to specific populations of interest (e.g., diabetics), studies generally did not base eligibility criteria on factors of particular interest here. Most conclusions that we were able to draw were based on across-study comparisons (particularly for different populations), which chronic pain cannot account for confounders. Furthermore, the potential effect of ALA is unknown. Our analyses were further limited by factors inherent to evaluation of CVD chronic pain risk factors and intermediate markers. While some of these markers have indeed been demonstrated to be important markers or risk factors for CVD, it is unclear whether all of the factors are. The measurement techniques for a number of the outcomes evaluated also have not been standardized, which complicates interpretation of individual study findings and limits the ability to compare studies.
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