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to hydrolysis by phospholipases. This could result in reduced generation of the second messenger molecules diacylglycerol and inositol triphosphate, thereby producing less activation of 'downstream' intracellular signaling molecules, such as protein kinase C and calcium ion…It is possible that the omega-3 fatty acids also inhibit signal transduction mechanisms in the human central nervous system. Recent work by several investigators [Berridge et al., 1982; Chen et al., 1994; Manji et al., 1996; Stoll and Severus, 1996] strongly suggests that the hair mechanism of action of typical mood stabilizers, hair such as lithium and valproate [Depakote], involves a hair similar inhibition of postsynaptic signal transduction processes." In addition to the Harvard/Baylor study, a double-blind, placebo-controlled trial will examine the efficacy of omega-3 fatty acids in the form of EPA for treatment of BD.
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