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A treatment study could assess a respiratory outcome, mediators of inflammation, or safety. A primary prevention study needed to estimate asthma prevalence or incidence, although case-control studies medical news employing outcomes pertinent to this question were also acceptable. A secondary prevention study required a long-term assessment of respiratory function to permit, for example, the observation of a maintained decrement in the need for medication in response to asthma exacerbations. Two levels of screening for relevance, medical news and two reviewers per level, were employed (bibliographic records, then full articles). Calibration exercises preceded each step of the screening process. medical news Excluded studies were noted as to the reason for their ineligibility using a modified QUOROM format.7
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