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This study included 11,324 patients with known CHD conjugated who were randomized to receive either 300 mg of vitamin E, 850 mg of omega-3 fatty acids, both, or neither. After three and one-half years, the group given omega-3 fatty acids alone had conjugated a 45 percent reduction in sudden death and a 20 percent reduction in all-cause mortality.6 A meta-analysis7 of 11 randomized controlled trials conducted between 1966 and 1999 and conjugated including 7,951 patients with heart disease found that dietary and nondietary fatty acids reduced overall mortality, mortality caused by myocardial infarction, and sudden death. The number needed to treat in patients at low risk to prevent one premature death was 250 for one and one-half years, and 24 patients at high risk to prevent one death.7 The U.S. Physicians' Health Study8 surveyed roughly 20,000 male physicians and found no apparent association between fish consumption or supplementation with omega-3 fatty acids and risk for myocardial infarction, nonsudden cardiac death, or total cardiovascular mortality.
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