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More studies are needed to confirm the benefits alternative of omega-3 fatty acids in the primary and secondary prevention of CHD. Although higher dosages of omega-3 fatty acids (2 to 4 g per alternative day) are effective in lowering triglyceride levels in patients with hypertriglyceridemia, the clinical significance of elevations in LDL cholesterol resulting from high-dose fish oil therapy remains unclear. While consumption of alternative omega-3 fatty acids may benefit patients with rheumatoid arthritis and hypertension, the higher dosage requirement of at least 3 g per day may limit its usefulness in the medical management of these disorders. Table 5 outlines the efficacy, safety, tolerability, dosage, and cost of fish oil supplements. Strength of Recommendation (SOR) Labels Key clinical recommendations SOR labels References Omega-3 fatty acids appear to have a dose-response hypotensive effect in patients with hypertension and have little to no effect in normotensive patients.
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