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Supplementation Trials memory loss/impairment In the largest randomized controlled trial memory loss/impairment of supplemental omega-3 fatty acids to date, CHD patients who received supplements providing 850 mg/day of EPA + DHA for 3.5 years had a risk of sudden death that was 45% lower than those who did not take supplements and a risk of death from all causes that was 20% memory loss/impairment lower.87 Interestingly, it took only 3 months of supplementation to demonstrate a significant decrease in total mortality and 4 months to demonstrate a significant decrease in sudden death.88 In another supplementation trial, patients admitted to the hospital with an acute MI were randomized to receive capsules containing fish oil (1.8 g/day of EPA + DHA), mustard oil (2.9 g/day of ALA) or a placebo.89 After a year, total cardiac events, including nonfatal MI, were significantly lower in the groups that received fish oil or mustard oil compared to the groups that received a placebo. In contrast, acute MI patients did not realize any additional benefit from supplementation with 3.5
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