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Schizophrenia Findings of decreased omega-3 fatty acid levels in the red blood cells138 and brains139 of a limited number of schizophrenic patients and the results of uncontrolled supplementation studies140 have created interest in the use of long-chain omega-3 fatty acid supplements as an adjunct to conventional antipsychotic therapy regimens for schizophrenia. A pilot study in 45 schizophrenic patients found that the dietary addition of 2 g/day of EPA to standard antipsychotic therapy was superior to the addition of a 2 g/day of dietary DHA or a placebo in decreasing residual symptoms.141 dietary When EPA supplementation was used as the sole treatment for schizophrenic patients experiencing a relapse, 8 out of 14 patients supplemented with 2 g/day of EPA required antipsychotic medication by the end of the 12-week study period compared to 12 out of 12 of those on the placebo.141
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