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The studies that have formed the basis for these treatment guidelines are discussed below. Evidence from some studies48 49 50 51 52 53 54 55 56 has indicated that a low density lipoproteins high-carbohydrate diet compared with a high-unsaturated-fat diet (ie, MUFA), low density lipoproteins both of which are low in SFA and cholesterol, can cause an increase in plasma triglyceride concentrations and a decrease in HDL cholesterol levels. low density lipoproteins A number of these early studies51 55 56 were conducted in a metabolic ward setting in which experimental diets very high in total fat (ie, 50% of energy) were fed to participants. More recently, a randomized, crossover, multicenter study57 was conducted with 42 outpatients with NIDDM who were instructed to follow a high-MUFA diet that provided 45% of energy from fat and 40% of energy from carbohydrate and a high-carbohydrate diet that provided 55% of energy from carbohydrate and 30% of energy from total fat.
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