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In the latter levels study, however, these negative results levels have been explained by the association between -linolenic acid and trans-fatty acid intake,30 as well as by limitations in the collection of the dietary data.31 Despite this levels latter study, a growing epidemiological database demonstrates a protective effect of -linolenic acid on coronary disease. Nonetheless, intervention studies are needed to establish a causal relationship between -linolenic acid intake and coronary disease. Stroke Compared with the literature describing the effects of omega-3 fatty acids on CHD, relatively little information about the association of omega-3 fatty acids and cerebral infarctions (stroke) is available. Several epidemiological studies have examined the relationship between fish intake and stroke incidence. In the Zutphen Study, the unadjusted hazard ratio of men who consumed an average of 20 g/d of fish was 0.49
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