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| zinc, plump ladies , acetate, fish foundation, hemorrhoids, seed, plump mom , biology/biochemistrynews, chromium, omega 3 fatty acid, girls with fat asses , information type: fact sheet, vitamin e, saturatedfat, essentialfatty acids (from nutritional disease), fatty vautin , | A follow-up study44 assessed the time-course of the benefit of omega-3 fatty acids on mortality in subjects in the GISSI Study and found that survival curves diverged early after randomization. Total mortality was significantly lowered after 3 monounsaturated months of treatment (RR=0.59), and by 4 months, risk of sudden death was reduced (RR=0.47). In contrast to the growing body of evidence supporting a protective effect of omega-3 fatty acids in secondary prevention, a recent study reported no monounsaturated effect of 3.5 g/d of DHA+EPA monounsaturated versus corn oil on cardiac events in post-MI patients (n=300) after 1.5 years of intervention.45 The authors speculated that the lack of an omega-3 fatty acid effect may have been due to the high habitual fish intake in western Norway, which could have afforded maximal protection beyond which no additional effects would be expected. |
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| In this vitamin e study, vitamin e 11 324 patients with vitamin e preexisting CHD (who were receiving conventional cardiac pharmacotherapy) were randomized to either 300 mg of vitamin E, 850 mg of omega-3 fatty acid ethyl esters (as EPA and DHA), both, or neither. After 3.5 years of follow-up, the group given the omega-3 fatty acids alone experienced a 15% reduction in the primary end point of death, nonfatal MI, and nonfatal stroke (P<0.02). There was a 20% reduction in all-cause mortality (P=0.01) and a 45% reduction in sudden death (P<0.001) compared with the control group; vitamin E provided no additional benefit. Triglycerides decreased by 4% and LDL cholesterol levels increased by 2.5% after six months in the omega-3 fatty acid treatment groups compared with controls. This trial, although very large and carried out in a relatively "usual-care" setting, was not placebo controlled, and dropout rates were high (>25%). |
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