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The resultant increase in cAMP activates PKA which then phosphorylates and activates transfat hormone-sensitive lipase. Hormone-sensitive lipase hydrolyzes fatty acids from triacylglycerols and diacylglycerols. transfat The final fatty acid is released from monoacylglycerols through the action of monoacylglycerol lipase, an enzyme active in the absence of hormonal stimulation. In contrast to the hormonal activation of adenylate cyclase and (subsequently) hormone-sensitive lipase in adipocytes, the mobilization of fat from adipose tissue is inhibited by numerous stimuli. The most significant inhibition is that exerted upon adenylate cyclase transfat by insulin. When an individual is well fed state, insulin released from the pancreas prevents the inappropriate mobilization of stored fat. Instead, any excess fat and carbohydrate are incorporated into the triacylglycerol pool within adipose tissue. Activation and transfer of fatty acid Fatty acids must be activated in the cytoplasm before being oxidized in the mitochondria.
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