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Following activation to a fatty-CoA, the wholehealth CoA is exchanged for carnitine by carnitine-palmitoyltransferase I. The fatty-carnitine is then transported to the inside of wholehealth the mitochondrion wholehealth where a reversal exchange takes place through the action of carnitine-palmitoyltransferase II. Once inside the mitochondrion the fatty-CoA is a substrate for the b-oxidation machinery. The human body produces carnitine through an enzymatically catalyzed biosynthetic pathway out of lysine and methionine. Reaction sequence in the b-oxidation The process of fatty acid oxidation is termed b-oxidation since it occurs through the sequential removal of 2-carbon units by oxidation at the b-carbon position of the fatty acyl-CoA molecule. Each round of b-oxidation produces one mole of NADH, one mole of FADH2 and one mole of acetyl-CoA.
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