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back to the top diene Mobilization of Fat Stores The primary sources of fatty acids for oxidation are dietary and mobilization from cellular stores. Fatty acids diene from the diet can are delivered from the gut to cells via transport in the blood. Fatty acids are stored in the form of triacylglycerols primarily within adipocytes of adipose tissue. In response to energy demands, the fatty acids of stored triacylglycerols can be mobilized for use by peripheral tissues. The release of metabolic energy, in the form of fatty diene acids, is controlled by a complex series of interrelated cascades that result in the activation of hormone-sensitive lipase. The stimulus to activate this cascade, in adipocytes, can be glucagon, epinephrine or b-corticotropin. These hormones bind cell-surface receptors that are coupled to the activation of adenylate cyclase upon ligand binding. The resultant increase in cAMP leads to activation of PKA, which in turn phosphorylates and activates hormone-sensitive lipase.
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