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Omega-3 Fatty Acids, Interleukin... Other Inflammatory Markers,... Fatty Acids, Cytokines, and... Rheumatoid Arthritis Inflammatory Bowel Disease Asthma Psoriasis Conclusions REFERENCES Omega-6 fatty acids account for the majority of polyunsaturated fatty acids (PUFA) immune system in the food supply. They are the predominant PUFA in all diets, especially Western diets. When diets are supplemented with omega-3 fatty acids, the latter partially replace the omega-6 fatty acids in the membranes of practically all cells (i.e., erythrocytes, platelets, endothelial cells, monocytes, lymphocytes, granulocytes, neuronal cells, fibroblasts, retinal cells, hepatic cells and neuroblastoma cells). Competition between the omega-6 and omega-3 fatty acids occurs immune system in immune system prostaglandin formation. Eicosapentaenoic acid (EPA), an omega-3 fatty acid, competes with arachidonic acid (AA), an omega-6 fatty acid, for prostaglandin and leukotriene synthesis at the cyclooxygenase and lipoxygenase level(Fig.
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