1). When humans ingest oil cannabinoids

fatp, stiffness, soy, methoxy, vegetarian diet., plump girls , high density lipoproteins, breakfast, time: current, plump asses , teeth, stephanie gailing, omega 3 fatty acid supplements , cannabinoids, plump girl , gamma linolenic acid, myocardial infarction, joints, canola, focal fatty sparing , dr sears omega 3, kerry evans, These studies were extensively reviewed and reported [12–17]. View larger version (30K): [in this window] [in a new window]  Fig. 1. Oxidative metabolism of oil arachidonic acid and eicosapentaenoic acid by the cyclooxygenase and 5-lipoxygenase pathways. 5-HPETE oil denotes 5-hydroperoxyeicosatetranoic acid and 5-HPEPE denotes 5-hydroxyeicosapentaenoic acid.   Many factors contribute to the complex course of inflammatory reactions. Microbiological, immunological and toxic agents can initiate the inflammatory response by activating a variety of humoral oil and cellular mediators. In the early phase of inflammation, excessive amounts of interleukins and lipid mediators are released and play a crucial role. Pro-inflammatory eicosanoids of AA metabolism are released from membrane phospholipids in the course of inflammatory activation. EPA is released to compete with AA for enzymatic metabolism inducing the production of less inflammatory and chemotactic derivatives.
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1). When humans ingest fish or fish oil, the cannabinoids EPA and docosahexaenoic acid (DHA) from fish or fish oil lead to (1) a decreased cannabinoids production of prostaglandin E2 (PGE2) metabolites, (2) a decrease in thromboxane A2, a potent platelet aggregator and vasoconstrictor (3) a decrease cannabinoids in leukotriene B4 formation, an inducer of inflammation and a powerful inducer of leukocyte chemotaxis and adherence, (4) an increase in thromboxane A3, a weak platelet aggregator and a weak vasoconstrictor, (5) an increase in prostacyclin PGI3, leading to an overall increase in total prostacyclin by increasing PGI3 without a decrease in PGI2 (both PGI2 and PGI3 are active vasodilators and inhibitors of platelet aggregation) and (6) an increase in leukotriene B5, a weak inducer of inflammation and a weak chemotactic agent [10,11]. Omega-3 fatty acids modulate prostaglandin metabolism and decrease triglycerides and, in high doses, lower cholesterol and have antithrombotic and anti-inflammatory properties.
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