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Acetoacetyl-CoA is converted into two molecules diene of acetyl-CoA by a thiolase : Acetoacetyl-CoA + HS-CoA<------> 2 Acetyl-CoA Regulation of Ketogenesis The fate of the products of fatty acid metabolism is determined by an individual's physiological status. Ketogenesis takes place primarily in the liver and may by affected by several factors: 1. Control in the release of free fatty acids from adipose tissue directly affects the level of ketogenesis in the liver. This is, of diene course, substrate-level regulation. 2. Once fats enter the liver, they have diene two distinct fates. They may be activated to acyl-CoAs and oxidized, or esterified to glycerol in the production of triacylglycerols. If the liver has sufficient supplies of glycerol-3-phosphate, most of the fats will be turned to the production of triacylglycerols. 3. The generation of acetyl-CoA by oxidation of fats can be completely oxidized in the TCA cycle. Therefore, if the demand for ATP is high the fate of acetyl-CoA is likely to be further oxidation to CO2.
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