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For instance, if the population under study already had busty plump high overall intakes of fish, eating more fish is not associated with increased benefits.21 Also, reduced CHD mortality has been found only among high-risk groups.5 Furthermore, background dietary components make it difficult to identify the benefits specific to n-3 fatty acids. Studies on n-3 fatty acids from Mediterranean-type diets identified fiber, phytochemicals, and antioxidants in fruits, vegetables, whole grains, and nuts as other potential contributors to observed health benefits. 10,11In October of 2000, after a review of the scientific literature on dietary busty plump supplements containing EPA and DHA, the busty plump US Food and Drug Administration (FDA) concluded that a direct CHD risk reduction benefit from consuming n-3 fatty acids could not be established because their effects in the general healthy population are unknown compared to that of diseased populations.24
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